decreased water holding capacity are believed to skin barrier dysfunction. It was surprising that we found positive correlation between TEWL and water holding capacity in AD. Conclusions: The results of TEWL and water holding capacity suggest that the barrier function of stratum corneum is impaired in AD patients. On the one hand, further studies should be required to explain the unexpected correlation between TEWL and water holding capacity. Both TEWL and water holding capasity didn’t correlate with AXR sweating volume. This appeared that the 2 factors are not under the influence of the AXR sweating at the same site.