455. Automated Lentiviral Transduction of T Cells with CARS Using the CliniMACS Prodigy

@article{Nickolay2016455AL,
  title={455. Automated Lentiviral Transduction of T Cells with CARS Using the CliniMACS Prodigy},
  author={Lauren E. Nickolay and U. Mock and B. Phillip and G. W. Cheung and H. Zhan and K. Peggs and I. Johnston and A. Kaiser and M. Pule and A. Thrasher and W. Qasim},
  journal={Molecular Therapy},
  year={2016},
  volume={24}
}
T lymphocytes are exhibiting enormous potential in early phase clinical trials in patients with haematological malignancies. However, the complex procedures involved in the ex-vivo modification of T cells is labour intensive and currently limited to a small number of centres with the required infrastructure and expertise. To simplify procedures and widen applicability for clinical therapies, we have adopted the CliniMACS Prodigy platform to automate these multifaceted cell manufacturing… Expand
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  • A. Gee
  • Business, Medicine
  • Best practice & research. Clinical haematology
  • 2018