4124 Identification of glycosaminoglycans in age-related macular deposits

  title={4124 Identification of glycosaminoglycans in age-related macular deposits},
  author={Mike Kliffen and J G N Huijmans and Cornelia M. Mooy and Theodorus M Luider and S. Kerkvliet and P. T. V. M. de Jong},
  journal={Vision Research},
We investigated the presence and localization of glycosaminoglycans in basal laminar deposit and drusen in age-related maculopathy. Conventional histological staining techniques and monoclonal antibodies specific for several glycosaminoglycans were used on paraffin-embedded human maculae. Furthermore, macular homogenates were analyzed with two-dimensional electrophoresis. Quantitative analysis of glycosaminoglycans was done spectrophotometrically using dimethylmethylene blue… CONTINUE READING
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