40 Sphingosine 1-phosphate activation of MAP kinase - involvement of PI 3-kinase and protein kinase C

@inproceedings{Conway199740S1,
  title={40 Sphingosine 1-phosphate activation of MAP kinase - involvement of PI 3-kinase and protein kinase C},
  author={A. Conway and Nigel J Pyne and Susan Pyne},
  year={1997}
}
In addition to its proposed intracellular role 111, sphingosine 1phosphate (SphP) may belong to a new class of extracellular lysophospholipid mediators which bind to specific cell surface receptors. SphP has been reported to induce neurite retraction 121, open K' channels [3,4], evoke Ca2' entry [3] and to stimulate phospholipase D and DNA binding of AP-I [ 1 1. In addition, we have previously shown that SphP regulates the MAPK cascade in guinea-pig airway smooth muscle (ASM) in a pertussis… CONTINUE READING

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