4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney.

  title={4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney.},
  author={Tobias Petras and Werner G. Siems and T. Grune},
  journal={Free radical biology & medicine},
  volume={19 5},
The cytotoxic lipid peroxidation product 4-hydroxynonenal (HNE) was infused into rat kidney. During the first 2 min a rapid degradation of a 100 microM HNE solution was demonstrated. After 5 min the consumption rate of 4-HNE reached a steady state of about 75 nmoles/ml. The total HNE consumption rate was about 200 nmoles/g w.w./min. The excretion rate into urine was about 0.1% of total HNE consumption. It could be demonstrated that the HNE-mercapturic acid formation takes place in the kidney… CONTINUE READING


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