4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.

  title={4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.},
  author={Kathleen S. Montine and Pum Joon Kim and Sandy J Olson and William R. Markesbery and Thomas J. Montine},
  journal={Journal of neuropathology and experimental neurology},
  volume={56 8},
Increasing age and inheritance of the epsilon 4 allele of apolipoprotein E (APOE4) are significant risk factors for sporadic and late onset familial Alzheimer disease (AD); however, the mechanisms by which either leads to AD are unknown. Numerous studies have associated advancing age with increased indices of oxidative challenge to brain, and with still further increased oxidative damage to relevant brain regions in AD patients. A major consequence of oxidative damage to brain is lipid… CONTINUE READING


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