4-bromo-7-hydroxyindan oxime--a new potent spermicidal agent.

@article{Yu19874bromo7hydroxyindanON,
  title={4-bromo-7-hydroxyindan oxime--a new potent spermicidal agent.},
  author={Z H Yu and Zhi-ping Gu and Xiufang Zhang and Fanghao Wan},
  journal={International journal of andrology},
  year={1987},
  volume={10 6},
  pages={
          741-6
        }
}
  • Z. H. Yu, Z. Gu, +1 author F. Wan
  • Published 1 December 1987
  • Medicine
  • International journal of andrology
The spermicidal effect of eleven chelating agents with a ring structure was evaluated using human spermatozoa. All were potent spermicides in vitro. 4-Bromo-7-hydroxyindan oxime (S-11) was the most potent and its lowest effective concentration for immobilizing sperm within 20 sec was 0.02 mg/ml; its toxicity was also the lowest of the compounds tested with an acute LD50 of 2936 mg/kg. In rabbits, S-11 caused no local irritation to the conjunctiva or quadriceps femoris muscle at a concentration… Expand
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