4-Substitutedphthalazines and phthalazinones: synthesis, characterization and β-adrenergic blocking activity

@article{Abouzid20124SubstitutedphthalazinesAP,
  title={4-Substitutedphthalazines and phthalazinones: synthesis, characterization and β-adrenergic blocking activity},
  author={Khaled A. M. Abouzid and Nadia Abdalla Khalil and Eman Mohamed Ahmed},
  journal={Medicinal Chemistry Research},
  year={2012},
  volume={22},
  pages={1057-1064}
}
Novel 4-(4-bromophenyl)phthalazine and phthalazinone derivatives connected through 2-propanol spacer to N-substituted piperazine residue were synthesized. All the new compounds were screened for their effect on β-adrenergic blocking activity on the norepinephrine-induced precontracted aortic ring module. Most test compounds displayed appreciable β-adrenolytic activity compared to propranolol as a reference standard. The results have shown that compounds 3a, 3d, 3e and 7c displayed appreciable… CONTINUE READING