4 Small GTPases : Mechanisms Linking Membrane Traffic to Cytoskeleton During Neuritogenesis

During neurite extension, the protrusive activity of the neuronal growth cone is mediated by the coordination of membrane traffic, adhesion to the cell substrate, and reorganization of the cytoskeleton that includes the dynamic rearrangement of actin filaments at the peripheral region of the growth cone. The small GTPases of the Rho family are important… (More)