Rules related to the safety of cosmetic products are imposed by the Council Directive 76/768/EEC (Cosmetics Directive) of 27 July 1976 (with subsequent amendments and adaptations). Article 2 states that: "A cosmetic product put on the market within the Community must not cause damage to human health when applied under normal or reasonably foreseeable conditions of use ..." Article 7 explains that "... the manufacturer shall take into consideration the general toxicological profile of the ingredient, its chemical structure and its level of exposure."

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@inproceedings{Basketter20044S, title={4 . Skin Sensitisation}, author={David A. Basketter and Silvia Casati and G. Frank Gerberick and P. D. Griem and Barry Philips and Andrew P. Worth}, year={2004} }