4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.

@article{Gotti19984OxystilbeneCA,
  title={4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.},
  author={Cecilia Gotti and B. Balestra and Milena Moretti and Gianenrico Rovati and Luca Maggi and Giuseppe Rossoni and Ferruccio Berti and Luigi Villa and M. Pallavicini and Francesco Clementi},
  journal={British journal of pharmacology},
  year={1998},
  volume={124 6},
  pages={1197-206}
}
1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and studied their selective effect on neuronal nicotinic acetylcholine receptor (AChR) subtypes. 2. MG 624, F3, F3A and F3B inhibited of 125I-alphaBungarotoxin (alphaBgtx) binding to neuronal chick optic lobe (COL) membranes, with nM affinity, but inhibited 125I-alphaBgtx binding to TE671 cell-expressed… CONTINUE READING