4-O-methylhonokiol inhibits serious embryo anomalies caused by nicotine via modulations of oxidative stress, apoptosis, and inflammation.

@article{Lin20144OmethylhonokiolIS,
  title={4-O-methylhonokiol inhibits serious embryo anomalies caused by nicotine via modulations of oxidative stress, apoptosis, and inflammation.},
  author={Chunmei Lin and Jung-min Yon and Jin Tae Hong and Jong Kwon Lee and Jayoung Jeong and In-Jeoung Baek and Beom jun Lee and Young Won Yun and Sang-Yoon Nam},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2014},
  volume={101 2},
  pages={125-34}
}
BACKGROUND Since the increasing smoking rate among women has resulted in higher rates of embryonic malformations, it is important to search for an efficient and inexpensive agent that can help reduce the rate of serious fetal anomalies caused by maternal cigarette smoking. In this study, the bioavailability of 4-O-methylhonokiol isolated from Magnolia officinalis was first demonstrated in the mouse embryos exposed to nicotine using a whole embryo culture system. METHODS Mouse embryos on… CONTINUE READING

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2 Excerpts

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