4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway.

@article{Lee20114OMethylhonokiolAM,
  title={4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway.},
  author={Young Jung Lee and Im Seup Choi and Mi Park and Yuk Mo Lee and Ju Kyoung Song and Young Hee Kim and Ki Ho Kim and Dae Yeon Hwang and Jae Hwang Jeong and Yeo Pyo Yun and Ki-Wan Oh and Jae Kyung Jung and Sang Bae Han and Jin Tae Hong},
  journal={Free radical biology & medicine},
  year={2011},
  volume={50 1},
  pages={66-77}
}
Presenilin 2 (PS2) mutation increases Aβ generation and neuronal cell death in the brains of Alzheimer disease (AD) patients. In a previous study, we showed that increased oxidative damage and activation of extracellular signal-regulated kinase (ERK) were associated with Aβ generation and neuronal cell death in neuronal cells expressing mutant PS2. In this study, we show that oral treatment with 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, for 3 months (1.0mg/kg… CONTINUE READING

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