4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
@article{Duan20174NonylphenolIA, title={4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.}, author={Peng Duan and Chunhui Hu and Chao Quan and Tingting Yu and Wenting Huang and Wei Chen and Sha Tang and Yuqin Shi and Francis L. Martin and Ke-di Yang}, journal={Toxicology letters}, year={2017}, volume={267}, pages={ 21-31 } }
48 Citations
Mutual promotion of apoptosis and autophagy in prepubertal rat testes induced by joint exposure of bisphenol A and nonylphenol.
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Evidence is provided that autophagy and PI3K/Akt/m TOR signaling pathway are involved in regulating rats primary SCs cell-cycle arrest due to ZEA in vitro, and to some extent, ZEA-induced Autophagy plays a protective role in this process.
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Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis
- BiologyInternational journal of molecular sciences
- 2017
Study of cultured SCs confirmed enhanced autophagic response to ethanol toxicity, which was cytoprotective based on decreased viability of SCs upon blocking autophagy with 3-methyladenine (3-MA), and may have significant implications for male fertility.
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Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide
- Biology, MedicineHuman & experimental toxicology
- 2020
It was found that flutamide activated the Atg7-Atg3-Lc3 pathway through the UPR pathway, caused cells excessive autophagy and apoptosis, and inhibited the formation of penile and testicular blood vessels by activating UPR and affecting the messenger RNA level of vascular endothelial growth factor and hypoxia-inducible factor 1.
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- Biology, ChemistryBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
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MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death
- Biology, ChemistryCell Death & Disease
- 2019
It is demonstrated that MeHg induces mTOR-independent autophagy through JNK/Vps34 complex pathway, which further promotes autophagosome accumulation and neuronal cell death, and implies that inhibiting JNK or downregulation of Vps34 decreased autophagic accumulation and alleviated MeHG-induced neuronal cellDeath.
Zearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells
- Biology, ChemistryScientific Reports
- 2018
Investigation of the molecular mechanisms of the destruction of cytoskeletal structure by Zearalenone in mouse-derived TM4 cells revealed that ZEA altered the cytoskeleton structure via oxidative stress - autophagy- ER stress pathway in mouse TM4 Sertoli cells.
References
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