4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.

@article{Duan20174NonylphenolIA,
  title={4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.},
  author={Peng Duan and Chunhui Hu and Chao Quan and Tingting Yu and Wenting Huang and Wei Chen and Sha Tang and Yuqin Shi and Francis L. Martin and Ke-di Yang},
  journal={Toxicology letters},
  year={2017},
  volume={267},
  pages={
          21-31
        }
}
The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone
TLDR
Evidence is provided that autophagy and PI3K/Akt/m TOR signaling pathway are involved in regulating rats primary SCs cell-cycle arrest due to ZEA in vitro, and to some extent, ZEA-induced Autophagy plays a protective role in this process.
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
TLDR
NP attenuated the proliferation, differentiation and stemness maintenance of SSCs while promoting apoptosis and oxidative stress and may be related to the PI3K/AKT/mTOR pathway.
Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis
TLDR
Study of cultured SCs confirmed enhanced autophagic response to ethanol toxicity, which was cytoprotective based on decreased viability of SCs upon blocking autophagy with 3-methyladenine (3-MA), and may have significant implications for male fertility.
Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
TLDR
It is found that ISO exposure inhibited cell viability and colony growth, activated apoptotic pathway, and triggered dysregulated autophagy by activating the AMPK/mTOR/p70S6K pathway.
Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide
  • H. Yu, K. Wen, Y. Zhu
  • Biology, Medicine
    Human & experimental toxicology
  • 2020
TLDR
It was found that flutamide activated the Atg7-Atg3-Lc3 pathway through the UPR pathway, caused cells excessive autophagy and apoptosis, and inhibited the formation of penile and testicular blood vessels by activating UPR and affecting the messenger RNA level of vascular endothelial growth factor and hypoxia-inducible factor 1.
MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death
TLDR
It is demonstrated that MeHg induces mTOR-independent autophagy through JNK/Vps34 complex pathway, which further promotes autophagosome accumulation and neuronal cell death, and implies that inhibiting JNK or downregulation of Vps34 decreased autophagic accumulation and alleviated MeHG-induced neuronal cellDeath.
Zearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells
TLDR
Investigation of the molecular mechanisms of the destruction of cytoskeletal structure by Zearalenone in mouse-derived TM4 cells revealed that ZEA altered the cytoskeleton structure via oxidative stress - autophagy- ER stress pathway in mouse TM4 Sertoli cells.
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References

SHOWING 1-10 OF 61 REFERENCES
4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.
Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways.
4‐Nonylphenol induces disruption of spermatogenesis associated with oxidative stress‐related apoptosis by targeting p53‐Bcl‐2/Bax‐Fas/FasL signaling
TLDR
Taken together, NP‐induced apoptosis, hormonal deficiencies, and depletion of fructose potentially impairs spermatogenesis and sperm function.
Se-Allylselenocysteine induces autophagy by modulating the AMPK/mTOR signaling pathway and epigenetic regulation of PCDH17 in human colorectal adenocarcinoma cells.
TLDR
Results reveal that ASC is an effective inducer of autophagy through regulating the AMPK/mTOR and PCDH17 expression via epigenetic modification.
Mitogen-activated protein kinase and Akt pathways are involved in 4-n-nonyphenol induced apoptosis in mouse Sertoli TM4 cells.
Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy
TLDR
Autophagy inhibition seems to enhance the vulnerability of gastric epithelial cells as a combination of ASA with 3-methyladenine exacerbated rat gastric damage and AGS cell apoptosis.
Zearalenone induces apoptosis and cytoprotective autophagy in primary Leydig cells.
BPA-induced apoptosis of rat Sertoli cells through Fas/FasL and JNKs/p38 MAPK pathways.
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