4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.

@article{Duan20164NonylphenolIA,
  title={4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.},
  author={Peng Duan and Chunhui Hu and Chao Quan and Tingting Yu and Wei Zhou and Meng Yuan and Yuqin Shi and Ke-di Yang},
  journal={Toxicology},
  year={2016},
  volume={341-343},
  pages={
          28-40
        }
}
4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells
TLDR
Results indicate that IRI stimulates the ROS-related JNK- and p38-MAPK pathways to promote autophagy-dependent apoptosis, and a combination of IRI with a pharmacological Autophagy enhancer may be a promising therapeutic strategy against gastric cancer.
Nonylphenol Induces Apoptosis through ROS/JNK Signaling in a Spermatogonia Cell Line
TLDR
It is found that cell viability significantly decreased and apoptosis increased in a dose-dependent manner when GC-1 spg cells were exposed to NP, and that NP increased reactive oxygen species (ROS) generation, suggesting that ROS-induced activation of the MAPK signaling pathway is the molecular mechanism of NP-induced apoptosis in GC- 1 spg Cells.
Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages
TLDR
Rg1 significantly suppressed apoptosis induced by serum deprivation in macrophage and could effectively induce the autophagic flux by attenuating serum deprivation-induced apoptosis in Raw264.7 macrophages through activating the AMPK/mTOR signaling pathway.
Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway
TLDR
This study provided the evidence that FLC promoted autophagy in mice’ TM4 Sertoli cells and that this process may involve ROS-mediated AKT/mTOR signaling pathways.
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
TLDR
NP attenuated the proliferation, differentiation and stemness maintenance of SSCs while promoting apoptosis and oxidative stress and may be related to the PI3K/AKT/mTOR pathway.
Elevation of autophagy rescues spermatogenesis by inhibiting apoptosis of mouse spermatocytes
TLDR
Hypoxia inhibits autophagy, which further enhances hypoxia-induced apoptosis of mouse spermatocytes by promoting caspase-8 activation in a time-dependent manner, suggesting that combined application of apoptosis inhibition and autophagic activation might be a therapeutic strategy for treating hypoxIA-induced male infertility.
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References

SHOWING 1-10 OF 62 REFERENCES
Nonylphenol‐induced apoptotic cell death in mouse TM4 Sertoli cells via the generation of reactive oxygen species and activation of the ERK signaling pathway
TLDR
The results suggest that NP induces apoptosis in mouse TM4 Sertoli cells via ROS generation and ERK activation.
α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway
TLDR
It is concluded that α-solanine induces autophagy to exert anti-proliferative activity by triggering ER stress and inhibiting Akt/mTOR signaling pathway.
The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway.
TLDR
The profound reduction in cell number was observed in combination treatment with FKB and Akt/p 38 MAPK inhibitors, indicating that the disruption of Akt and p38 MAPK cascades plays a functional role in FKB-induced G(2)/M arrest and apoptosis in HSC-3 cells.
Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.
TLDR
Treatment with THC induced autophagic cell death in human HL-60 promyelocytic leukemia cells by increasing autophage marker acidic vascular organelle (AVO) formation and demonstrated the anticancer efficacy of THC by inducing autophagy as well as provided a potential application for the prevention of human leukemia.
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy
TLDR
The report that B5 induces apoptosis in two human cervical cancer cell lines, CaSki and SiHa, as evidenced by the downregulation of XIAP, activation of caspases and cleavage of PARP, and the ability of B5 to activate autophagy in cells was confirmed.
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