4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.

@article{Duan20164NonylphenolIA,
  title={4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.},
  author={Peng Duan and Chunhui Hu and Chao Quan and Tingting Yu and Wei Zhou and Meng Yuan and Yuqin Shi and Ke-di Yang},
  journal={Toxicology},
  year={2016},
  volume={341-343},
  pages={
          28-40
        }
}
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4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
Nonylphenol induced apoptosis and autophagy involving the Akt/mTOR pathway in prepubertal Sprague-Dawley male rats in vivo and in vitro.
Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell.
Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells
TLDR
Results indicate that IRI stimulates the ROS-related JNK- and p38-MAPK pathways to promote autophagy-dependent apoptosis, and a combination of IRI with a pharmacological Autophagy enhancer may be a promising therapeutic strategy against gastric cancer.
Nonylphenol Induces Apoptosis through ROS/JNK Signaling in a Spermatogonia Cell Line
TLDR
It is found that cell viability significantly decreased and apoptosis increased in a dose-dependent manner when GC-1 spg cells were exposed to NP, and that NP increased reactive oxygen species (ROS) generation, suggesting that ROS-induced activation of the MAPK signaling pathway is the molecular mechanism of NP-induced apoptosis in GC- 1 spg Cells.
Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages
TLDR
Rg1 significantly suppressed apoptosis induced by serum deprivation in macrophage and could effectively induce the autophagic flux by attenuating serum deprivation-induced apoptosis in Raw264.7 macrophages through activating the AMPK/mTOR signaling pathway.
Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway
TLDR
This study provided the evidence that FLC promoted autophagy in mice’ TM4 Sertoli cells and that this process may involve ROS-mediated AKT/mTOR signaling pathways.
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
TLDR
NP attenuated the proliferation, differentiation and stemness maintenance of SSCs while promoting apoptosis and oxidative stress and may be related to the PI3K/AKT/mTOR pathway.
Elevation of autophagy rescues spermatogenesis by inhibiting apoptosis of mouse spermatocytes
TLDR
Hypoxia inhibits autophagy, which further enhances hypoxia-induced apoptosis of mouse spermatocytes by promoting caspase-8 activation in a time-dependent manner, suggesting that combined application of apoptosis inhibition and autophagic activation might be a therapeutic strategy for treating hypoxIA-induced male infertility.
Inhibition of autophagy aggravated 4‐nitrophenol‐induced oxidative stress and apoptosis in NHPrE1 human normal prostate epithelial progenitor cells
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References

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TLDR
The results suggest that NP induces apoptosis in mouse TM4 Sertoli cells via ROS generation and ERK activation.
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TLDR
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