4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species.

@article{Arima20064Nitroquinoline1F,
  title={4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species.},
  author={Yaeno Arima and Chikako Nishigori and Toru Takeuchi and Shigenori Oka and Kanehisa Morimoto and Atsushi Utani and Yoshiki Miyachi},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2006},
  volume={91 2},
  pages={382-92}
}
4-Nitroquinoline 1-oxide (4NQO) is thought to elicit its carcinogenicity by producing DNA adducts after being metabolized to 4-hydroxyaminoquinoline 1-oxide, which forms 8-hydroxydeoxyguanosine (8OHdG), oxidative damage. To determine whether reactive oxygen species (ROS) are involved in the generation of 8OHdG by 4NQO, we used high-performance liquid… CONTINUE READING