4-Nitro-3-phenylphenol has both androgenic and anti-androgenic-like effects in rats

@article{Trisomboon20154Nitro3phenylphenolHB,
  title={4-Nitro-3-phenylphenol has both androgenic and anti-androgenic-like effects in rats},
  author={Jiratthiya Trisomboon and Chunmei Li and A. Suzuki and G. Watanabe and K. Taya},
  journal={The Journal of Reproduction and Development},
  year={2015},
  volume={61},
  pages={134 - 137}
}
To investigate the effect of endocrine disruption of 4-nitro-3-phenylphenol (PNMPP) on immature male Wistar-Imamichi rats, the rat pituitary was exposed to PNMPP (10–5–10–9 M) for 24 h with or without gonadotropin-releasing hormone (GnRH) in experiment I. In addition, the Leydig cells (10–5–10–9 M) were exposed to PNMPP for 24 h with or without human chronic gonadotropin (hCG) in experiment II. Our results showed that the PNMPP at 10–5–10–7 M suppressed follicle-stimulating hormone (FSH) and… Expand

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