4-N-hydroxy-L-2,4-diaminobutyric acid. A strong inhibitor of glutamine synthetase.


Analogues of glutamic acid were synthesized and evaluated for their inhibitory activity toward glutamine synthetase (EC; GS). The title compound, 4-N-hydroxy-L-2,4-diaminobutyric acid (NH-DABA), showed a potent inhibitory activity against GS from both sheep brain and soybean. The inhibition is competitive with respect to glutamic acid and the Ki… (More)


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@article{Fushiya19884NhydroxyL24diaminobutyricAA, title={4-N-hydroxy-L-2,4-diaminobutyric acid. A strong inhibitor of glutamine synthetase.}, author={Shinji Fushiya and Katsuya Maeda and Tomoo Funayama and Soichiro Nozoe}, journal={Journal of medicinal chemistry}, year={1988}, volume={31 2}, pages={480-3} }