4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels

@article{Abiero20194MeOPCPA3,
  title={4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels},
  author={Arvie R. Abiero and Chrislean Jun Botanas and Raly James Perez Custodio and Leandro Val Sayson and Mikyung Kim and Hyun Jun Lee and Hee Jin Kim and Kun Won Lee and Youngdo Jeong and Joung-wook Seo and In Soo Ryu and Yong Sup Lee and Jae Hoon Cheong},
  journal={Psychopharmacology},
  year={2019},
  volume={237},
  pages={757-772}
}
Rationale A high number of synthetic dissociative drugs continue to be available through online stores, leading to their misuse. Recent inclusions in this category are 4-MeO-PCP and 3-MeO-PCMo, analogs of phencyclidine. Although the dissociative effects of these drugs and their recreational use have been reported, no studies have investigated their abuse potential. Objectives To examine their rewarding and reinforcing effects and explore the mechanistic correlations. Methods We used conditioned… 
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References

SHOWING 1-10 OF 74 REFERENCES
Rewarding and reinforcing effects of the NMDA receptor antagonist–benzodiazepine combination, zoletil®: Difference between acute and repeated exposure
Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice
TLDR
A role for dopamine D1-like but not D2-like receptors in ethanol’s unconditioned rewarding effect as indexed by CPP is supported.
The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation
TLDR
The abuse potential of buphedrone is suggested and the involvement of the dopaminergic system in the establishment of its rewarding properties is demonstrated.
The effects of haloperidol on amphetamine-and methylphenidate-induced conditioned place preferences and locomotor activity
TLDR
The results suggest that the reinforcing properties of MPD and AMP may be mediated by different mechanisms, while the locomotor stimulant effects of the two drugs have common neural substrates.
Role of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Mediating Reward
TLDR
The present results suggest that concurrent activation of D1- and D2-type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes.
Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self‐administration in rats
TLDR
Cocaine self‐administration produces long‐lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence.
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