4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels

  title={4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels},
  author={Arvie R. Abiero and Chrislean Jun Botanas and Raly James Perez Custodio and Leandro Val Sayson and Mikyung Kim and Hyun Jun Lee and Hee Jin Kim and Kun Won Lee and Youngdo Jeong and Joung-wook Seo and In Soo Ryu and Yong Sup Lee and Jae Hoon Cheong},
Rationale A high number of synthetic dissociative drugs continue to be available through online stores, leading to their misuse. Recent inclusions in this category are 4-MeO-PCP and 3-MeO-PCMo, analogs of phencyclidine. Although the dissociative effects of these drugs and their recreational use have been reported, no studies have investigated their abuse potential. Objectives To examine their rewarding and reinforcing effects and explore the mechanistic correlations. Methods We used conditioned… 
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