4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases.

@article{Poli20084HydroxynonenalproteinAA,
  title={4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases.},
  author={Giuseppe Poli and Fiorella Biasi and Gabriella Leonarduzzi},
  journal={Molecular aspects of medicine},
  year={2008},
  volume={29 1-2},
  pages={67-71}
}
The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein adducts actually elude the metabolism of the aldehyde, particularly active in the liver, so that they can be easily detected in the hepatic tissue itself and in peripheral blood, and… CONTINUE READING
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