4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2.

@article{Chen20054HydroxynonenalIA,
  title={4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2.},
  author={Zhihua Chen and Yoshiro Saito and Yasukazu Yoshida and Azusa Sekine and Noriko Noguchi and Etsuo Niki},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 51},
  pages={41921-7}
}
4-Hydroxynonenal (4-HNE) is one of the major end products of lipid peroxidation. It has been widely accepted that 4-HNE can induce oxidative stress, implicating into extensive stress-related diseases. In the present study, however, 4-HNE was found to exert adaptive cytoprotective effect at low concentrations, which was primarily through induction of thioredoxin reductase 1 (TR1) via transcriptional activation of NF-E2-related factor 2 (Nrf2). Pretreatment with 4-HNE at sublethal concentrations… CONTINUE READING

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