4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.

@article{DelloStritto20164HydroxynonenalDA,
  title={4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.},
  author={Daniel J DelloStritto and Pritam Sinharoy and Patrick J Connell and Joseph N Fahmy and Holly C. Cappelli and Charles Kumar Thodeti and Werner J Geldenhuys and Derek S Damron and Ian N Bratz},
  journal={Free radical biology & medicine},
  year={2016},
  volume={101},
  pages={10-19}
}
We demonstrated previously that TRPV1-dependent regulation of coronary blood flow (CBF) is disrupted in diabetes. Further, we have shown that endothelial TRPV1 is differentially regulated, ultimately leading to the inactivation of TRPV1, when exposed to a prolonged pathophysiological oxidative environment. This environment has been shown to increase lipid peroxidation byproducts including 4-Hydroxynonenal (4-HNE). 4-HNE is notorious for producing protein post-translation modification (PTM) via… CONTINUE READING
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