4-Hydroxylation of estrogens as marker of human mammary tumors.

  title={4-Hydroxylation of estrogens as marker of human mammary tumors.},
  author={Joachim G. Liehr and Melissa J Ricci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 8},
Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those tissues in which this hormone is predominantly converted to the catechol metabolite 4-hydroxyestradiol by a specific 4-hydroxylase enzyme, whereas tumors fail to develop in organs in which 2-hydroxylation predominates. We have now found that microsomes prepared from human mammary adenocarcinoma and fibroadenoma predominantly catalyze the metabolic 4-hydroxylation of… CONTINUE READING


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