4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion.

  title={4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion.},
  author={Christophe Broca and Mich{\`e}le Manteghetti and Ren{\'e} Gross and Y G Baissac and Molly Jacob and Pierre Petit and Yves Sauvaire and G{\'e}rard Ribes},
  journal={European journal of pharmacology},
  volume={390 3},
4-Hydroxyisoleucine, a peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity. To investigate the structural requirements for this stimulating effect, the insulinotropic activity of the major isomer (2S,3R,4S) of 4-hydroxyisoleucine, in the presence of 8. 3 mM glucose, was compared to that of (1) its minor isomer (2R,3R, 4S) (2) its lactone form, (3) classical structurally related amino acids, and (4) synthetic… CONTINUE READING