4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.

  title={4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.},
  author={Koji Uchida},
  journal={Progress in lipid research},
  volume={42 4},
  • Koji Uchida
  • Published 2003 in Progress in lipid research
The onset of lipid peroxidation within cellular membranes is associated with changes in their physiochemical properties and with the impairment of enzymatic functions located in the membrane environment. There is increasing evidence that aldehydic molecules generated endogenously during the process of lipid peroidation are causally involved in most of the pathophysiological effects associated with oxidative stress in cells and tissues. 4-Hydroxy-2-nonenal (HNE), among them, is believed to be… CONTINUE READING
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