4-Hydroxy-17-methylincisterol, an inhibitor of DNA polymerase-alpha activity and the growth of human cancer cells in vitro.

@article{Togashi19984Hydroxy17methylincisterolAI,
  title={4-Hydroxy-17-methylincisterol, an inhibitor of DNA polymerase-alpha activity and the growth of human cancer cells in vitro.},
  author={H. J. Togashi and Yoshiyuki Mizushina and Masaharu Takemura and Fumio Sugawara and Hiroyuki Koshino and Yasuaki Esumi and Jun Uzawa and Hiromichi Kumagai and Akio Matsukage and S. Yoshida and Kengo Sakaguchi},
  journal={Biochemical pharmacology},
  year={1998},
  volume={56 5},
  pages={
          583-90
        }
}
An ergosterol derivative, 4-hydroxy-17-methylincisterol (HMI), was found to be an inhibitor of mammalian DNA polymerases in vitro. HMI inhibited the activity of calf thymus DNA polymerase alpha (pol. alpha). Among the polymerases tested, pol. alpha was the most sensitive to inhibition by HMI, and the inhibition was concentration dependent. The inhibitory effect of HMI on pol. alpha was almost the same as that shown by aphidicolin, a well-known potent pol. alpha inhibitor. HMI had relatively… Expand
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  • Y. Mizushina
  • Biology, Medicine
  • Bioscience, biotechnology, and biochemistry
  • 2009
TLDR
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