4-HPR induce apoptosis in cervical cancer cells through means of endoplasmic reticulum stress

@inproceedings{Tao20094HPRIA,
  title={4-HPR induce apoptosis in cervical cancer cells through means of endoplasmic reticulum stress},
  author={Sa-sa Tao},
  year={2009}
}
Objective To explore anti-tumor effect and its cancer prevention mechanism of drug 4-HPR.Methods MIT assay was performed to evaluate the growth inhibition effect of cervical cancer cells by 4-HPR.Annexin V-FITC and propidinm iodide(PI)double staining was performed to detect apoptotic cells.Oxidation-sensitive fluorescent dye DCFH-DA Was used for detection of intracellular reactive oxygen species(ROS).Western blot was used to detect Bcl-2 and CHOP protein expression.Results 4-HPR inhibits the… Expand