4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase.

Abstract

4'-Fluorinated analogue of 9-[(1'R,2'S,3'R)-2',3'-dihydroxy-cyclopentan-1'-yl]adenine (DHCaA) and their related analogues were systematically synthesized under the Mitsunobu and palladium(0) coupling conditions followed by fluorination with inversion of the configuration by using diethylaminosulfur trifluoride, respectively. 4'-beta-Fluoro DHCaA and 2-amino… (More)

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@article{Kitade20064FluorinatedCN, title={4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase.}, author={Yukio Kitade and Takayuki Ando and Tsuyoshi Yamaguchi and Ayumi Hori and Masayuki Nakanishi and Yoshihito Ueno}, journal={Bioorganic & medicinal chemistry}, year={2006}, volume={14 16}, pages={5578-83} }