4-Chloro-m-cresol: a specific tool to distinguish between malignant hyperthermia-susceptible and normal muscle.

@article{HerrmannFrank19964ChloromcresolAS,
  title={4-Chloro-m-cresol: a specific tool to distinguish between malignant hyperthermia-susceptible and normal muscle.},
  author={Annegret Herrmann-Frank and Mark W Richter and Frank Lehmann-Horn},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 1},
  pages={149-55}
}
Single-channel recordings have indicated that ryanodine receptor (RyR1) mutation Arg615Cys of porcine malignant hyperthermia-susceptible (MHS) muscle is not directly associated with the enhanced caffeine sensitivity of MH(S) muscle [1]. In the present study, the effect of a novel activator of RyR1, 4-chlorom-cresol (4-CmC), was investigated on high-affinity… CONTINUE READING