4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice

@article{Paulis20044Caffeoyl15quinideIR,
  title={4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice},
  author={Tomas de Paulis and Patricia A. Commers and Adriana Zacarias Farah and Jiali Zhao and Michael P. McDonald and Ruggero Galici and Peter R. Martin},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={146-153}
}
RationaleCinnamoylquinides are formed from the corresponding chlorogenic acids during coffee roasting. Instant coffee has been shown to displace binding of the mu opioid receptor antagonist, [3H]naloxone, but the putative active agent, feruloylquinide, has not been characterized.ObjectivesThe goal was to identify the active agent(s) in coffee by measuring the binding affinity of individual cinnamoyl-1,5-quinides to the human mu opioid receptor, and determine the effects of these compounds on… CONTINUE READING
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