4-Bromo-2,5-dimethoxyphenylisopropylamine, a new centrally active amphetamine analog.

@article{Shulgin19714Bromo25dimethoxyphenylisopropylam,
  title={4-Bromo-2,5-dimethoxyphenylisopropylamine, a new centrally active amphetamine analog.},
  author={Alexander T. Shulgin and Thornton Sargent and Claudio Naranjo},
  journal={Pharmacology},
  year={1971},
  volume={5 2},
  pages={
          103-7
        }
}
A new centrally active halo-amine, 4-bromo-2,5 dimethoxyphenylisopropylamine, is described. In clinical evalua tion it proved to enhance effectively both emotional and in tellectual perception, without the imagery and perceptual distortions commonly encountered with many of the chemically related psychotomimetics. These properties suggest a potential valuable role in conjunction with psychotherapy. 
Sulfur analogs of psychotomimetic amines.
TLDR
The syntheses and physical properties are described for 2,5-dimethoxy-4-methylthiophenylethylamine and 2,4-5-trimethoxyphenylisopropylamine wherein the methylthio group replaces a methoxy group or a methyl group, respectively.
Centrally active N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine).
TLDR
Measurements of the pharmacological activity of a series of analogs with substituents on the nitrogen atom indicated that the central activity decreased with the increasing bulk of the N-substituent.
4-Bromo-2,5-dimethoxyphenethylamine: identification of a new street drug.
TLDR
NMR, UV, and mass spectral data used in the identification of 4-bromo-2,5-dimethoxyphenethylamine as a street drug are presented.
Synthesis of 123I-labelled 4-iodo-2, 5-dimethoxyphenylisopropylamine
A rapid and convenient synthesis of the psychotomimetic agent 4-iodo-2, 5-dimethoxyphenylisopropylamine is described, incorporating the radioisotope 123I (T1/2 13 hr). With the amine function of 2,
An Evaluation of the Potential for Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs
Encountering a novel controlled-substance analog (designer drug) has become a distinct possibility for all forensic drug laboratories. 3,4-Methylenedioxyamphetamine (MDA) in particular is a receptive
Quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines.
TLDR
Qualitative models based on both regiospecific lipophilicity or electron densities and also metabolic conversion to reactive intermediates are presented, indicating that the 2-X-substituted-4,5-dimethoxyphenylisopropylamines are unusually hydrophilic.
Identification and characterization of 2,5-dimethoxy-3,4-dimethyl-β-phenethylamine (2C-G)--a new designer drug.
TLDR
The study indicated that the marketing of analogues of controlled substances poses a real analytical challenge for forensic laboratories, and the application of sophisticated methods is often required for unequivocal identification of a new substance.
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  • A. Shulgin
  • Chemistry
    Journal of medicinal chemistry
  • 1968
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