4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs.

  title={4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs.},
  author={Fat-Chun Tony Chang and David L. Spriggs and Bernard J. Benton and Shannon A. Keller and Benedict R. Capacio},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={38 1},
  • F. ChangD. Spriggs B. Capacio
  • Published 1 July 1997
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
The extent to which cardiorespiratory infirmity and other sublethal effects of saxitoxin (STX) and tetrodotoxin (TTX) can be reversed by 4-aminopyridine (4-AP) was investigated in guinea pigs chronically instrumented for the concurrent electrophysiological recordings of electrocorticogram (ECoG), diaphragmatic electromyogram (DEMG), Lead II electrocardiogram, and neck skeletal muscle electromyogram. Animals were intoxicated with either STX or TTX (2 and 3 microg/kg, im) to produce a state of… 

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