4-Aminopyridine can induce release of calcium from the sarcoplasmic reticulum of frog heart.

Abstract

4-Aminopyridine (4-AP), a K(+)-channel blocker, has been associated with cellular Ca2+ movements in various excitable tissues but its interaction with intracellular Ca2+ pools has not been described. Spontaneously beating ventricular strips of frog hearts responded to 4-AP (1.6 x 10(-2) M) by contracture that was susceptible to tolerance development when 4… (More)

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Cite this paper

@article{Ozgl20004AminopyridineCI, title={4-Aminopyridine can induce release of calcium from the sarcoplasmic reticulum of frog heart.}, author={Meltem Ozg{\"u}l and Coşkun Silan and Okan Yillar and C K{\"u}ç{\"u}kh{\"u}sey{\'i}n}, journal={Journal of basic and clinical physiology and pharmacology}, year={2000}, volume={11 1}, pages={57-62} }