4-Aminopyridine Improves Spatial Memory in a Murine Model of HIV-1 Encephalitis

@article{Keblesh20094AminopyridineIS,
  title={4-Aminopyridine Improves Spatial Memory in a Murine Model of HIV-1 Encephalitis},
  author={James P. Keblesh and Huanyu Dou and Howard E. Gendelman and Huangui Xiong},
  journal={Journal of Neuroimmune Pharmacology},
  year={2009},
  volume={4},
  pages={317-327}
}
HIV-1-associated neurocognitive disorders (HAND) remains a significant source of morbidity in the era of wide spread use of highly active antiretroviral therapy. Disease is precipitated by low levels of viral growth and glial immune activation within the central nervous system. Blood borne macrophage and microglia affect a proinflammatory response and release viral proteins that affects neuronal viability and leads to death of nerve cells. Increasing evidence supports the notion that HAND is… CONTINUE READING
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