4-Amino-6-methylhept-2-enoic acid: a leucine analogue and potential probe for localizing sites of proteolytic control in the hepatocyte.

@article{Wert19924Amino6methylhept2enoicAA,
  title={4-Amino-6-methylhept-2-enoic acid: a leucine analogue and potential probe for localizing sites of proteolytic control in the hepatocyte.},
  author={J. Wert and G. Miotto and M. Kadowaki and G. Mortimore},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={186 3},
  pages={
          1327-32
        }
}
  • J. Wert, G. Miotto, +1 author G. Mortimore
  • Published 1992
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • A recent analysis of leucine analogues has suggested that the carboxyl group is not required for mediating low concentration proteolytic inhibition in liver cells. In designing a probe to localize the regulatory site(s), we tested this hypothesis by synthesizing an analogue with a 2-carbon insert between the carboxyl and alpha-carbon. The Wittig product, a trans olefin, was fully active. Surprisingly, low concentration activity was lost when the double bond was eliminated by hydrogenation… CONTINUE READING
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