4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid aminotransferase.

  title={4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid aminotransferase.},
  author={Ryszard Andruszkiewicz and Richard B Silverman},
  journal={The Journal of biological chemistry},
  volume={265 36},
A variety of alkyl-substituted 4-aminobutanoic acid derivatives, including a homologous series of 3-alkyl-4-aminobutanoic acid analogues, 4-methyl isomer analogues, the 3,3-dimethyl analogue, and (E)-4-amino-3-methyl-2-butenoic acid, were synthesized and tested as alternate substrates for purified gamma-aminobutyric acid aminotransferase from pig brain. All of the compounds were substrates, but their activities diminished as the size and bulk of the 3-alkyl substituent increased. Several… CONTINUE READING

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