4-Amino-2-arylamino-5-indoloyl/cinnamoythiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells.

@article{Juneja20134Amino2arylamino5indoloylcinnamoyth,
  title={4-Amino-2-arylamino-5-indoloyl/cinnamoythiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells.},
  author={Manisha Juneja and Uma Vanam and Sripriya Paranthaman and Asha Bharathan and Venugopal S Keerthi and Justus K Reena and Rajendran Rajaram and Kallikat N. Rajasekharan and Devarajan Karunagaran},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={63},
  pages={
          474-83
        }
}
Marine organisms provide several biologically active compounds that include alkaloids with high cytotoxic activity but only a few of them have so far reached clinical stage, due partly to their limited supply and complex structural features. In an attempt to develop novel anticancer compounds, we have now synthesized diaminoindoloylthiazoles (4a-c; DIT1-3) and diaminocinnamoylthiazoles (5a,b; DCT1-2) as analogs based on a topsentin scaffold and investigated the cytotoxic and apoptotic… CONTINUE READING

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