4-1BB-mediated immunotherapy of rheumatoid arthritis

  title={4-1BB-mediated immunotherapy of rheumatoid arthritis},
  author={Su Kil Seo and Jae Ho Choi and Young Ho Kim and Woo Jin Kang and Hyun Young Park and Jae Hee Suh and Beom Kyu Choi and Dass S. Vinay and Byoung S. Kwon},
  journal={Nature Medicine},
Collagen type II–induced arthritis is a CD4+ T-cell–dependent chronic inflammation in susceptible DBA/1 mice and represents an animal model of human rheumatoid arthritis. We found that development of this condition, and even established disease, are inhibited by an agonistic anti-4-1BB monoclonal antibody. Anti-4-1BB suppressed serum antibodies to collagen type II and CD4+ T-cell recall responses to collagen type II. Crosslinking of 4-1BB evoked an antigen-specific, active suppression mechanism… CONTINUE READING
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