4-1BB functions as a survival factor in dendritic cells.

  title={4-1BB functions as a survival factor in dendritic cells.},
  author={Beom Kyu Choi and Young Hoi Kim and Patrick M. Kwon and Sang Chan Lee and Sang Won Kang and Moon Sun Kim and Myoung Joo Lee and Byoung S. Kwon},
  journal={Journal of immunology},
  volume={182 7},
4-1BB (CD137) is expressed on dendritic cells (DCs) and its biological function has remained largely unresolved. By comparing 4-1BB-intact (4-1BB(+/+)) and 4-1BB-deficient (4-1BB(-/-)) DCs, we found that 4-1BB was strongly induced on DCs during the maturation and that DC maturation was normal in the absence of 4-1BB. However, DC survival rate was low in the absence of 4-1BB, which was due to the decreased Bcl-2 and Bcl-x(L) in 4-1BB(-/-) DCs compared with 4-1BB(+/+) DCs after DC maturation… CONTINUE READING