4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [corrected] induces CRM1-dependent p53 nuclear accumulation in human bronchial epithelial cells.

@article{Chen20104methylnitrosamino13pyridyl1butanoneI,
  title={4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [corrected] induces CRM1-dependent p53 nuclear accumulation in human bronchial epithelial cells.},
  author={Lixia Chen and Changxia Shao and E Berrobianco Cobos and Jia-sheng Wang and Weimin Gao},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={116 1},
  pages={206-15}
}
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [corrected] (NNK), a known tobacco-specific human lung carcinogen, is notorious for causing DNA damage. The tumor suppressor gene p53 has multiple functions in response to DNA damage. Besides being regulated by posttranslational modifications (PTMs), p53 function is modulated by nucleocytoplasmic shuttling factors (NSFs). In this study, the alterations of p53 protein after NNK exposure and the molecular mechanisms involved p53 PTMs and NSFs in… CONTINUE READING

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