4‐Nonylphenol induces disruption of spermatogenesis associated with oxidative stress‐related apoptosis by targeting p53‐Bcl‐2/Bax‐Fas/FasL signaling

@article{Duan20174NonylphenolID,
  title={4‐Nonylphenol induces disruption of spermatogenesis associated with oxidative stress‐related apoptosis by targeting p53‐Bcl‐2/Bax‐Fas/FasL signaling},
  author={Peng Duan and Chunhui Hu and Holly J. Butler and Chao Quan and Wei Chen and Wenting Huang and Sha Tang and Wei Zhou and Meng Yuan and Yuqin Shi and Francis L. Martin and Ke-di Yang},
  journal={Environmental Toxicology},
  year={2017},
  volume={32}
}
4‐Nonylphenol (NP) is a ubiquitous environmental chemical with estrogenic activity. Our aim was to test the hypothesis that pubertal exposure to NP leads to testicular dysfunction. Herein, 24 7‐week‐old rats were randomly divided into four groups and treated with NP (0, 25, 50, or 100 mg/kg body weight every 2 days for 20 consecutive days) by intraperitoneal injection. Compared to untreated controls, the parameters of sperm activation rate, curvilinear velocity, average path velocity, and… 
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The overall findings revealed that single or co‐exposure to BPA and NP at environmental concentrations affects the biochemical structures and properties of LCs.
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TLDR
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