4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.

@article{Summa200645dihydroxypyrimidineCA,
  title={4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.},
  author={Vincenzo Summa and Alessia Petrocchi and Victor G. Matassa and Cristina Gardelli and Ester Muraglia and Michael Rowley and Odalys Gonzalez Paz and Ralph Laufer and Edith S. Monteagudo and Paola Pace},
  journal={Journal of medicinal chemistry},
  year={2006},
  volume={49 23},
  pages={6646-9}
}
The dihydroxypyrimidine carboxamide 4a was discovered as a potent and selective HIV integrase strand transfer inhibitor. The optimization of physicochemical properties, pharmacokinetic profiles, and potency led to the identification of 13 in the dihydroxypyrimidine series and 18 in the N-methylpyrimidinone series having low nanomolar activity in the cellular HIV spread assay in the presence of 50% normal human serum and very good pharmacokinetics in preclinical species. 

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