4'-[Methyl-11C]-thiothymidine PET/CT for proliferation imaging in non-small cell lung cancer.

  title={4'-[Methyl-11C]-thiothymidine PET/CT for proliferation imaging in non-small cell lung cancer.},
  author={Ryogo Minamimoto and Jun Toyohara and Ayako Seike and Hideyuki Ito and Hisako Endo and Miyako Morooka and Kazuhiko Nakajima and Takuya Mitsumoto and Kimiteru Ito and Momoko Okasaki and Kiichi Ishiwata and Kazuo Kubota},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={53 2},
UNLABELLED A new tracer, 4'-[methyl-(11)C]-thiothymidine ((11)C-4DST), has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. This study evaluated the potential of (11)C-4DST PET/CT for imaging proliferation in non-small cell lung cancer (NSCLC), compared with (18)F-FDG PET/CT. METHODS Eighteen patients with lung lesions were examined by PET/CT using (11)C-4DST and (18)F-FDG. We constructed decay-corrected time-activity curves of 9 major regions as… CONTINUE READING
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