4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.

@article{Fajdeti20104OomegaQuinolylaminoalkylaminoprop,
  title={4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.},
  author={Andrea Fajdeti{\'c} and Hana {\vC}ip{\vc}i{\'c} Paljetak and Gorjana Lazarevski and Antun Hutinec and Sulejman Alihod{\vz}i{\'c} and Marko Derek and Vlado Stimac and Daniele Andreotti and Vitomir {\vS}unji{\'c} and J. M. Berg{\'e} and Stjepan Mutak and Miljenko Dumi{\'c} and Sergio Lociuro and David J. Holmes and Nata{\vs}a Mar{\vs}i{\'c} and Vesna Erakovi{\'c} Haber and Radan Spaventi},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 17},
  pages={6559-68}
}
Four macrolides-6-O-methyl-8a-aza-8a-homoerythromycin, clarithromycin, azithromycin and azithromycin 11,12-cyclic carbonate, have been selected for the construction of a series of new quinolone derivatives. The quinolone moiety is connected to the macrolide scaffold via a diaminoaklyl 4''-O-propionyl ester chain of varying length. At the terminus the linker is attached via one of the nitrogen atoms in the linker at C(6) or C(7) of the quinolone. Many of compounds described, particularly… CONTINUE READING