3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.

  title={3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.},
  author={Sarah M. Rothman and Nathan Herdener and Simonetta Camandola and Sarah J. Texel and Mohamed R. Mughal and Wei-na Cong and Bronwen Martin and Mark P. Mattson},
  journal={Neurobiology of aging},
  volume={33 4},
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most studies of the effects of stress in models of AD utilize acute adverse stressors of questionable clinical relevance. The goal of this work was to determine how chronic psychosocial stress affects behavioral and pathological outcomes in an animal model of AD, and to elucidate underlying mechanisms. A triple-transgenic mouse model of AD (3xTgAD mice) and nontransgenic control mice were used to test for an affect… CONTINUE READING


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