3p21, 5q21, and 9p21 allelic deletions are frequently found in normal bronchial cells adjacent to non-small-cell lung cancer, while they are unusual in patients with no evidence of malignancy.

@article{SanzOrtega20013p215A,
  title={3p21, 5q21, and 9p21 allelic deletions are frequently found in normal bronchial cells adjacent to non-small-cell lung cancer, while they are unusual in patients with no evidence of malignancy.},
  author={Juli{\'a}n Sanz-Ortega and Mar{\'i}a del Carmen S{\'a}ez and Elena Sierra and Antonio Torres and Jos{\'e} Luis Balibrea and Florentino Hernando and Juli{\'a}n Sanz-Esponera and Mar{\'i}a Jos{\'e} Beato Merino},
  journal={The Journal of pathology},
  year={2001},
  volume={195 4},
  pages={429-34}
}
Molecular cytogenetic and loss of heterozygosity (LOH) analyses of non-small-cell lung cancer (NSCLC) have shown frequent allelic deletions in a variety of chromosomes, such as 1p, 3p, 5q, 8p, 9p, 11p, 11q, and 17p. Allelic loss at 3p21, 9p21, and 5q21 has also been reported in premalignant epithelial lesions of the bronchus and in normal bronchial cells. These findings suggest that a tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. LOH… CONTINUE READING

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