3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

@article{Hill19813HbaclofenA3,
  title={3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain},
  author={David R. Hill and Norman G. Bowery},
  journal={Nature},
  year={1981},
  volume={290},
  pages={149-152}
}
The presence of a novel receptor for the neurotransmitter γ-aminobutyric acid (GABA) on peripheral autononric nerve terminals and in mammalian brain slices has been described recently1–4. This receptor differs from the classical GABA site as it is unaffected by recognized GABA antagonists such as bicuculline and is not sensitive to the majority of accepted GABA-mimetics such as 3-aminopropanesulphonic acid (3-APS) or isoguvacine. We propose to designate the classical site as the GABAA and the… 

The Autoradiographic Localization of Baclofen-Sensitive GABAB Sites in Rat Cerebellum

TLDR
It was obviously of great interest to determine the morphological distribution of these receptor sites in the mammalian nervous system and this report summarizes some of the preliminary findings.

Bicuculline‐ and Baclofen‐Insensitive γ‐Aminobutyric Acid Binding to Rat Cerebellar Membranes

Abstract: Up to 60% of γ‐[3H]aminobutyric acid ([3H]GABA) bound specifically to rat cerebellar membranes in the absence of Ca2+ was insensitive to the GABAA antagonist bicuculline and to the GABAB

Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.

Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord?

TLDR
It is reported here that GABAB sites, unlike GABAA sites, are present in high concentrations in laminae I, II, III and IV of the dorsal horn and that after the neonatal administration of capsaicin this binding is reduced by 40–50%.
...

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