3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.

@article{Coupet19793HSpiroperidolBT,
  title={3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.},
  author={J. Coupet and C. Rauh},
  journal={European journal of pharmacology},
  year={1979},
  volume={55 2},
  pages={
          215-8
        }
}
  • J. Coupet, C. Rauh
  • Published 1979
  • Chemistry, Medicine
  • European journal of pharmacology
  • The effects of loxapine and its hydroxylated metabolites 7-hydroxyloxapine and 8-hydroxyloxapine on 3H-spiroperidol binding to rat striatal membranes were investigated. Whereas 7-hydroxyloxapine and loxapine displayed strong affinities for 3H-spiroperidol binding sites, 8-hydroxyloxapine was essentially inactive. The potency of 7-hydroxyloxapine to displace 3H-spiroperidol is 1.5 times and 8 times those of haloperidol and chlorpromazine, respectively. These results suggest that the combined… CONTINUE READING
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