3DCoffee: combining protein sequences and structures within multiple sequence alignments.

@article{OSullivan20043DCoffeeCP,
  title={3DCoffee: combining protein sequences and structures within multiple sequence alignments.},
  author={Orla O'Sullivan and Karsten Suhre and Chantal Abergel and Desmond G. Higgins and C{\'e}dric Notredame},
  journal={Journal of molecular biology},
  year={2004},
  volume={340 2},
  pages={385-95}
}
Most bioinformatics analyses require the assembly of a multiple sequence alignment. It has long been suspected that structural information can help to improve the quality of these alignments, yet the effect of combining sequences and structures has not been evaluated systematically. We developed 3DCoffee, a novel method for combining protein sequences and structures in order to generate high-quality multiple sequence alignments. 3DCoffee is based on TCoffee version 2.00, and uses a mixture of… CONTINUE READING