3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.

@article{Felts20103DVO,
  title={3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.},
  author={Richard L Felts and Kedar Narayan and Jacob D Estes and Dan Shi and Charles Mac Trubey and Jing Fu and Lisa M. Hartnell and Gordon T Ruthel and Douglas K Schneider and Kunio Nagashima and Julian W. Bess and Sina Bavari and Bradley C. Lowekamp and Donald Bliss and Jeffrey D Lifson and S. Anand Subramaniam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 30},
  pages={13336-41}
}
The efficiency of HIV infection is greatly enhanced when the virus is delivered at conjugates between CD4+ T cells and virus-bearing antigen-presenting cells such as macrophages or dendritic cells via specialized structures known as virological synapses. Using ion abrasion SEM, electron tomography, and superresolution light microscopy, we have analyzed the spatial architecture of cell-cell contacts and distribution of HIV virions at virological synapses formed between mature dendritic cells and… CONTINUE READING
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